(Boston Children’s Hospital) Botulinum toxins are FDA-approved and widely used. Although they are safe and effective, they can drift away from the site of injection, reducing efficacy and causing side effects. New work from Boston Children’s Hospital on botulinum B combined structural modeling and genetic engineering to enable the toxin to bind more tightly to nerve cells and stay in place. This led to more effective, longer-lasting local muscle paralysis and reduced toxicity.

Original source: https://www.eurekalert.org/pub_releases/2020-03/bch-bab031720.php